Um novo estudo descobriu que o sangue jovem não melhorou significativamente a vida útil de camundongos velhos. No entanto, o sangue velho diminuiu significativamente a vida útil dos camundongos jovens.
Em um novo estudo, camundongos jovens e velhos foram unidos cirurgicamente de modo que compartilharam a circulação sanguínea por três meses. De acordo com os resultados, os ratos velhos não se beneficiaram significativamente em termos de vida útil. Por outro lado, os camundongos jovens que foram expostos ao sangue de animais velhos tiveram uma vida útil significativamente menor em comparação com os camundongos que compartilharam sangue com outros camundongos jovens. O estudo foi publicado em 22 de julho na revista peer-reviewed Pesquisa de rejuvenescimento.
Pesquisa em terapias de rejuvenescimento em laboratório e clínica. Crédito: Mary Ann Liebert, Inc., editores
A parabiose heterocrônica é uma ferramenta de pesquisa usada para avaliar o efeito de órgãos e de fatores transmitidos pelo sangue em animais jovens e idosos. Menos controlada que a troca direta de sangue, a parabiose é um modelo de compartilhamento de sangue entre dois animais conectados cirurgicamente. Iryna Pishel, da Kyiv National Taras Shevchenko University e Bienta Ltd, em Kyiv, Ucrânia, e coautores usaram a parabiose heterocrônica entre camundongos jovens e velhos e os controles isocrônicos por três meses. Em seguida, eles desconectaram os animais e estudaram os efeitos da união no sangue[{” attribute=””>plasma and animal lifespan.
“The most robust and interesting result of this study is the fact of a significant decrease in the lifespan of young mice from heterochronic parabiotic pairs,” state the investigators. “These data support our assumption that old blood contains factors capable of inducing aging in young animals. Finding and selective suppression of aging factor production in the organism could be the key research field for life extension,” they conclude.
Editor-in-Chief Irina Conboy, PhD, Professor, College of Engineering, University of California, Berkeley says “This work clarifies the question of whether the young blood or old blood control longevity, which has been debated (Nature 2005, Conboy, et. al). Are there lasting effects of heterochronic parabiosis and if so, is it a rejuvenation or aging? The work by the Pishel group established that the lifespan of the old mice does not increase after being parabiosed to young mice. In contrast, the young animals that were joined with the old mice suffer a shortened lifespan, even after being disconnected.
“This discovery is important in establishing the accurate direction for clinical anti-aging approaches and in providing key scientific evidence against the potency of the young blood factors in an aged organism. This work neatly follows the report previously published by this group that infusions of young blood plasma into mice do not increase their lifespan.”
On a very important note, Professor Pishel conducted these seminal studies as the Head of the Department at Kyiv National Taras Shevchenko University, yet composed the paper as a refugee, from data collected before the outbreak of war with Russia. Such important studies were interrupted by the war, and we hope that the research will soon continue and yield more breakthroughs.
Reference: “Three Month Heterochronic Parabiosis Has a Deleterious Effect on the Lifespan of Young Animals, Without a Positive Effect for Old Animals” by Tatiana Yankova, Tatiana Dubiley, Dmytro Shytikov and Iryna Pishel, 22 July 2022, Rejuvenation Research.
DOI: 10.1089/rej.2022.0029
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